Scientific Advisory Board
The Marodyne Medical Scientific Advisory Board (SAB) is comprised of world-renowned physicians, surgeons, biomedical scientists and bioengineers, each with a specific expertise central to the Marodyne Mission, and all committed to the development and evaluation of a safe, non-drug stem-cell based intervention for the effective and accelerated treatment of acute injury and chronic metabolic diseases such as osteoporosis, obesity, diabetes and bone marrow failure. Many of the SAB members have worked with the Low Intensity Vibration (LIV) signal, and have contributed to the basic (cell), applied (animal) and clinical understanding and potential applications of the LIV science and technology. Several members of the Marodyne SAB have received funding (e.g., National Institutes of Health, U.S. Army, National Aeronautics and Space Administration) to study basic and translational applications of low magnitude mechanical signals, including the study of the molecular regulators of the differentiation and proliferation of stem cells, the control of osteoblastogenesis and adipogenesis, the evaluation of the technology in preventing/reversing osteoporosis in the frail elderly, promoting bone mineral density in young women with osteoporosis, and the enhancement of the skeleton in children with metabolic disorders. The SAB provides insight into the scientific basis of the anabolic nature of the LIV signal, and provides advice and guidance on new directions for clinical applications of the science and technology.
Scott Boden, MD
Professor of Orthopaedic Surgery
Director, Emory Orthopaedics & Spine Center
Director, Whitesides Orthopaedic Research Laboratory
Emory University School of Medicine
Atlanta, Georgia
Dr. Boden received his B.A. and M.D. from the University of Pennsylvania and completed an Orthopaedic Residency at The George Washington University Medical Center, followed by a Spine Fellowship at Case Western Reserve University Hospitals. He has received the Volvo Award for Low Back Pain Research (4 times), The Marshal Urist Young Investigator Award, the North American Spine Society Outstanding Paper Award (7 times), and the AAOS/ORS Kappa Delta Research Award. He has received the Leon Wiltse Award for Outstanding Contributions to the field of spine surgery from the North American Spine Society. Dr. Boden has authored over 150 peer-reviewed articles on spine and basic science topics as well as 30 chapters and 7 textbooks. Dr. Boden's basic research focus has centered on gaining an understanding of the biology of spine fusion healing and bone graft substitutes as well as the molecular control of bone formation and gene therapy applications for bone and intervertebral disc cartilage regeneration. Dr. Boden's interests also include innovative health care delivery strategies in a managed care environment and he is Founder and Chairmen of the National Spine Network, a collaboration of 25 Spine Centers of Excellence around the U.S. focusing on outcomes research and quality improvement. For further information on Dr. Boden's research accomplishments and clinical focus, please visit his academic web-site at: http://www.emoryhealthcare.org/emory-orthopaedics-spine-hospital/index.html
John B. Buse, MD, PhD
Professor of Medicine
Chief, Division of Endocrinology
Director, Diabetes Center
Executive Associate Dean, Clinical Research
University of North Carolina School of Medicine
Dr. John B. Buse received his BS from Dartmouth College, his MD and PhD from Duke University and his clinical training at the University of Chicago. He joined the faculty of the University of North Carolina School of Medicine in 1994 where he is Professor of Medicine, Chief of the Division of Endocrinology, Director of the Diabetes Center and Executive Associate Dean for Clinical Research. His research focuses on the prevention and treatment of diabetes and its complications. He has participated in the leadership, design, analysis and conduct of over 100 multi-center clinical trials in the last fifteen years. He has chaired or participated in dozens of national and international committees focused on research oversight, development of clinical guidelines and promulgating treatment strategies in diabetes. Dr. Buse served at President for Medicine and Science at the American Diabetes Association in 2007 and 2008. He has received national and international recognition as a clinician and investigator. For further information on Dr. Buse, Please follow this link his academic website: http://medicine.med.unc.edu/uncdiabetes
Victor Frankel, MD, PhD, KNO
Professor of Orthopaedics
New York University
President (emeritus); Hospital for Joint Diseases
New York, New York
Dr. Frankel received his BA degree from Swarthmore College, and his MD degree from the University of Pennsylvania School of Medicine. His orthopaedic residency education was at the Hospital for Joint Diseases in New York City. He was a March of Dimes fellow at the University of Uppsala where he received a PhD for his work on understanding the biomechanics of the femoral neck. He then returned to the Hospital for Joint Diseases where he established the first biomechanics laboratory devoted to orthopaedic surgery. He is considered a world authority on orthopaedic biomechanics, biomaterials, total joint replacement devices, and state-of-the-art methods of fracture healing and Ilizarov limb-lengthening procedures. He has been Professor of Orthopaedic Surgery at Case Western University, and Chairman of Orthopaedic Surgery at the University of Washington. He was Chairman and Surgeon in Chief at the Hospital for Joint Diseases Orthopaedic Institute and President. He is the author and co-author of six books concerning orthopaedic biomechanics, many translated into foreign languages. He has authored 110 peer reviewed publications in understanding the interface between the biology and mechanics of bone and the musculoskeletal system, and the translation of this science into the orthopaedic clinic. He organized the first formal courses in orthopaedic biomechanics and lectured on the subject in numerous courses both in the US and abroad. He has received many awards for his pioneering scientific contributions, including the key awards by the Hip Society, The International Society for the Study of the Lumbar Spine, The Foot Society. In recognition of his central contributions to musculoskeletal health and orthopaedic surgery, he was named as a Knight Commander of the Order of the North Star by Sweden. He has served previously as the Chairman of the ASTM Committee on Surgical Implants and Chairman of the first FDA Orthopaedic Advisory Committee.
Vicente Gilsanz, MD, PhD
Professor of Pediatric
Professor of Radiology
Professor of Orthopaedics
Childrens Hospital of Los Angeles
Keck School of Medicine
University of Southern California
Dr. Gilsanz is the Director of the Childrens Imaging Research Program at the Children's Hospital Los Angeles and is board-certified in internal medicine, diagnostic radiology, and pediatric radiology. He is a Professor of Radiology, Pediatrics and Orthopedic Surgery at the Keck School of Medicine of the University of Southern California. His main research interests are determinants of bone gain during growth. Dr. Gilsanz was the principal investigator on the U.S. Army funded study which demonstrated that low magnitude mechanical signals are anabolic to bone and muscle in a cohort of young women with osteoporosis. More information on Dr. Gilsanz can be found on his USC academic website, at: http://www.usc.edu/programs/pibbs/site/faculty/gilsanz_v.htm
Douglas Kiel, MD, MPH
Director of Medical Research
Institute for Aging Research at Hebrew Senior Life
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts
Dr. Douglas P. Kiel received his BS from Duke University, his MD from the University of North Carolina School of Medicine, and an MPH in Epidemiology and Biostatistics at Boston University School of Public Health. He is currently the Director of Medical Research and Chair of the Senior Faculty Council at the Institute for Aging Research at Hebrew SeniorLife, and an Associate Professor of Medicine at Harvard Medical School. His research focuses on the prevention of osteoporotic fractures and musculoskeletal decline. He is the Principal Investigator of the Framingham Osteoporosis Study, which has identified multiple risk factors for osteoporosis and related fractures. The Framingham Osteoporosis Study has been a major contributor to recent genome wide association studies of bone density and other musculoskeletal phenotypes. Dr. Kiel has also led multiple NIH-funded clinical trials to prevent falls, bone loss and fractures in seniors. These studies include a trial of varying doses of vitamin D to prevent falls in nursing home residents, a study of hip protectors to prevent hip fracture, and he is currently leading a study of low magnitude mechanical stimulation to improve bone density, balance, strength, and muscle mass. He has published extensively on falls, including the UpToDate chapter on this topic. He was a contributing author to the Surgeon General's Report on Bone Health and Osteoporosis and serves on the editorial boards of the Journal of Clinical Densitometry and the Journal of Bone and Mineral Research, as well as the Scientific Advisory Committee and the Education Committee of the NOF. He is currently a member of the Council of the American Society for Bone and Mineral Research and the Clinical Trials Advisory Panel of the National Institute on Aging. Please follow this link to Professor Kiel's academic website: http://www.hebrewseniorlife.org/research.cfm?id=637
Stefan Judex, PhD
Director, Integrative Skeletal Adaptation and Genetics Laboratory
Associate Professor of Biomedical Engineering
Stony Brook University
Stony Brook, New York
Dr Stefan Judex received his BS and MS in mechanical engineering from the Technical University of Munich, his PhD in biomechanics from the University of Calgary, and post-doctoral training in molecular biology at Stony Brook University. He is currently the Director of the Integrative Skeletal Adaptation and Genetics Laboratory and an Associate Professor in the Department of Biomedical Engineering at Stony Brook University. Translational as well as basic research in his laboratory revolves around the genetic, molecular, and physical processes by which altered mechanical demand modulates the quantity and quality of the musculo-skeleton. Recent data from his laboratory indicate that physical signals, induced via low intensity vibration, can be effective even without producing deformations in the extracellular matrix, suggesting that mechanical interventions can be safe to a frail skeleton yet retain their anabolic potential. His research is funded by multiple sources including NIH and NASA. Dr. Judex has received several research awards from societies such as the International Society of Biomechanics, the American Society for Bone and Mineral Research, the World Congress of Biomechanics, or the Society for Advances in Mineral Metabolism. He is also the editorial board member of multiple scientific journals and a reviewer for more than 30 journals. For further information, please visit Professor Judex's academic website at http://bme.sunysb.edu/people/faculty/s_judex.html
Mary B. Leonard, MD, MSCE
Associate Professor of Pediatrics and Epidemiology
The Children's Hospital of Philadelphia
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
Dr. Mary B. Leonard received her B.S. from Northwestern University, her M.D. from Stanford University School of Medicine, and a Master's of Science in Clinical Epidemiology from the University of Pennsylvania. She is currently the Director of Research in the Division of Nephrology at the Children's Hospital of Philadelphia and a Senior Scholar in the University of Pennsylvania Center for Clinical Epidemiology and Biostatistics. She is an Associate Professor of Pediatrics and Epidemiology at the University of Pennsylvania. Her multidisciplinary research program is focused on the accurate assessment and diagnosis of osteoporosis in children with chronic disease, the detrimental effects of glucocorticoid therapy, muscle deficits and inflammation on bone development in varied pediatric disorders, the assessment of the unique effects of kidney disease on skeletal structure in children and adults using novel micro-imaging techniques, and the evaluation of low magnitude mechanical stimuli as a potential bone therapy in children with Crohn's disease. Her research program is supported by multiple NIH investigator-initiated grants, including 3 R01 grants. She was the Co-Chair of the International Society of Clinical Densitometry Pediatric Position Development Conference. She is a member of the Council of the American Society of Pediatric Nephrology, and an Associate Editor of the Journal of the American Society of Nephrology. More on Dr. Leonard's can be found on her academic website: http://www.cceb.upenn.edu/faculty/?id=28
Takashi Matsushita, MD, PhD
Professor and Director
Department of Orthopaedic Surgery
Teikyo University School of Medicine
Tokyo, Japan
Dr. Matsushita received his MD and DMSc from The University of Tokyo. He is currently the Professor and Director of Department of Orthopaedic Surgery, Teikyo University School of Medicine, the Board member of International Society for Fracture Repair, the President of Japanese Society for Fracture Repair, and the President of the Japanese Association for Orthopaedic Reconstruction and Ilizarov Method. His main scientific interests are mechanical stimulation for fracture healing, assessment of fracture healing, limb reconstruction and Ilizarov method. Dr. Matsushita was elected President of International A.S.A.M.I.(Association for the Study and Application of Ilizarov's Method) from 2004 to 2006, and Meeting chairman in 2006.
Jeffrey Pessin, Ph.D.
Judy R. & Alfred A. Rosenberg Professorial Chair in Diabetes Research
Director, Diabetes Research Center
Departments of Medicine and Molecular Pharmacology
Albert Einstein College of Medicine
Dr. Pessin received his B.A./MA. degrees from Brooklyn College, Brooklyn, NY and his Ph.D. degree from the University of Illinois at Urbana, Illinois. As an internationally recognized research scientist, Dr. Pessin has served on numerous scientific review panels, research boards and program development committees. He has also been an active in the management in the peer-review process serving as the past Editor-in-Chief for Endocrinology and the American Journal of Physiology (Endocrinology & Metabolism) and currently as an Editor for Diabetes. Dr. Pessin's research in Diabetes and insulin action has centered on the molecular analysis of receptor tyrosine kinase activity and regulation of proteins kinases, small GTP binding protein cascades that control the rate of glucose uptake and metabolism in skeletal muscle and adipose tissue. More recently his laboratory has been investigating the role of adult progenitor cells in the development of adiposity and mechanical signals that influence stem cell development. More on Dr. Pessin can be found on his academic website: http://www.einstein.yu.edu/diabetes/page.aspx
Clifford J. Rosen, M.D.
Director of Clinical and Translational Research, Maine Medical Center
Senior Scientist, Maine Medical Center Research Institute
Adjunct Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
Professor of Medicine, Tufts University School of Medicine, Boston, MA
NIAMS Scientific Advisory Board
FDA Advisory Board on Endocrinologic and Metabolic Drugs
Dr. Clifford J. Rosen, M.D. is the Director of Clinical and Translational Research and a Senior Scientist at Maine Medical Center's Research Institute. His other current positions include Adjunct Staff Scientist at the Jackson Laboratory, and Professor of Medicine at Tufts University School of Medicine. Dr. Rosen is the founder and Former Director of the Maine Center for Osteoporosis Research and Education. He was the first Editor-in-Chief of the Journal of Clinical Densitometry, is the current Editor-in-Chief of The Primer in Metabolic Bone Diseases, and just began a term as Associate Editor for JCEM. His publications include more than 300 peer-reviewed manuscripts, covering both clinical and basic bone biology. Dr. Rosen has overseen numerous phase II and III clinical trials, funded both privately and through the NIH. He is a member of the FDA Advisory Panel on Endocrinologic and Metabolic Drugs and a former chairperson of that committee. He was Permanent Chair of the NIH Review Panel for Skeletal Biology and Bone Diseases for 2002-2004, and is currently a member of the NIAMS Scientific Advisory Board. He served as president of the American Society for Bone and Mineral Research in 2002-2003, and was recently honored to present the Louis V. Avioli Memorial Lecture, “Bone Marrow Fat: Neighbor or Nemesis”, at the 30th Annual ASBMR Official Scientific Meeting in Montreal, Canada. Dr. Rosen's research interests include the genetic regulation of insulin-like growth factor relative to skeletal metabolism, PTH as an anabolic therapy, and the relationship between marrow adipogenesis and osteoblastogenesis. For more information on Dr. Rosen's research focus, please visit his website: http://www.mmcri.org/cctr/
Janet Rubin, MD
Professor, Department of Medicine
Professor, Department of Pharmacology
Professor, Department of Pediatrics
Professor, adjunct, Department of Bioengineering
University of North Carolina at Chapel Hill
Dr. Janet Rubin received her BA from Bryn Mawr College, her MD from Brown University, and training in Endocrinology and Metabolism at the University of California at San Diego. As a member of the Endocrinology Department at Emory University, she rose to Professor of Medicine. Dr Rubin relocated to the University of North Carolina at Chapel Hill in 2006. Her home appointment is in the Department of Medicine, and she has joint appointments in Pharmacology, Pediatrics and Bioengineering. She is Director of the Endocrinology/Metabolism T32 Training Grant, Director of the “K2R” seminar to aid junior faculty in developing RO1 grants which she developed with UNC-Chapel Hill's CTSA, and leads the Endocrine Division's “Topics in Molecular Endocrinology” seminar. Dr. Rubin sees patients with endocrine disorders at UNC's Faculty Practice, and directs the Densitometry Facility at the Highgate Specialty Center. Dr Rubin's research focuses on elucidating the signals by which mechanical forces regulate bone remodeling. Recently the laboratory discovered that mechanical factors directly inhibit the development of fat tissue from stem cells, further deciphering the signaling molecules critical to this regulation. Her laboratory's work is supported by grants from NIAMS at the NIH. Dr. Rubin currently serves as Co-Chair of the NIH Study Section “Skeletal Biology Structure & Regeneration” and previously was a standing member of the NIH Study Section “Skeletal Biology, Development and Disease”. As well, she has reviewed grants for the Veterans Affairs, American Society for Bone and Mineral Research Society, and the National Osteoporosis Foundation. She was an elected Council Member of the American Society for Bone and Mineral Research Society from 2005-2008, served as Chair of the Advocacy Committee and was a member of the Professional Practice Committee. She currently serves on the editorial board of the Journal of Bone and Mineral Research, as well as several research advisory boards. Please follow this link to Professor Rubin's academic website: http://www.med.unc.edu/mhi/Laboratories/rubin-lab