Webinar: Mechanical Signals as Anabolic Agents to Bone
By Ready Talk | Source: ASBMR (The American Society for Bone and Mineral Research)
Osteopenia, a condition of diminished bone mass, becomes osteoporosis when mechanical demands exceed the ability of the skeletal structure to support them. While poor bone quantity and quality are principal factors in osteoporosis, consequences of the disease are exacerbated by an age-related decrease in muscle strength and postural stability, markedly increasing the risk of falling and injury. While the great majority of treatment strategies for osteoporosis are pharmaco-centric, this webinar will explore the potential of exercise in general, and mechanical signals in particular, as the basis of a non-drug strategy to prevent bone loss and restore function of the musculoskeletal system.
Learning Objectives:
At the conclusion of this webinar, participants will be able to:
- Explain the role of exercise and mechanical signals as the basis of a non-drug strategy to prevent bone loss and restore function of the musculoskeletal system.
- Identify evidence from the clinic which indicates the sensitivity of bone to changes in its loading environment (e.g., chronic bed rest, spaceflight, running).
- Understand the mechanical challenges that bone must resist during functional loadbearing (e.g., strain environment of bone).
- Examine optimizing the mechanical regimen in the formation of bone (e.g., magnitude, cycles, duration, frequency).
- Identify the cellular targets and molecular cues which control the bone adaptive response (e.g., beta-catenin, WNT).
- Understand and identify early evidence that re-introducing mechanical signals to the diseased or injured musculoskeletal system can aid in recovery and rehabilitation.